Endothelial CRAC Channels

(CRAC) current. SOCE was proposed to regulate many EC functions, including proliferation, migration, angiogenesis, and barrier permeability. Prior studies have provided evidence that dysregulation of endothelial SOCE underlies endothelial dysfunction in several vascular diseases. Here, we highlight the role of SOCE in regulating EC function and explore the potential of targeting Orai channels to treat vascular diseases.