生物
SNP公司
遗传学
全基因组关联研究
单核苷酸多态性
基因
候选基因
奶牛
基因组
遗传关联
基因型
作者
J. Liu,Lingyang Xu,Xiangbin Ding,Yuru Ma
出处
期刊:Genes
[MDPI AG]
日期:2023-12-20
卷期号:15 (1): 12-12
标识
DOI:10.3390/genes15010012
摘要
This study was to explore potential SNP loci for reproductive traits in Chinese Holstein cattle and identify candidate genes. Genome-wide Association Study based on mixed linear model was performed on 643 Holstein cattle using GeneSeek Bovine 50 K SNP chip. Our results detected forty significant SNP loci after Bonferroni correction. We identified five genes (VWC2L, STAT1, PPP3CA, LDB3, and CTNNA3) as being associated with pregnancy ratio of young cows, five genes (PAEP, ACOXL, EPAS1, GLRB, and MARVELD1) as being associated with pregnancy ratio of adult cows, and nine genes (PDE1B, SLCO1A2, ARHGAP26, ADAM10, APBB1, MON1B, COQ9, CDC42BPB, MARVELD1, and HPSE2) as being associated with daughter pregnancy rate. Our study may provide valuable insights into identifying genes related to reproductive traits and help promote the application of molecular breeding in dairy cows.
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