前部缺血性视神经病变
医学
中间性中心性
神经科学
静息状态功能磁共振成像
视神经病变
顶叶下小叶
顶叶上小叶
功能磁共振成像
视神经
中心性
眼科
放射科
心理学
数学
组合数学
作者
H. Wang,Yan Xi,Qiuhuan Zhang,Qiong Wu,Lixin Qiu,Jian Zhou,Pengde Guo
标识
DOI:10.1016/j.clineuro.2023.108101
摘要
Nonarteritic anterior ischemic optic neuropathy (NAION) is a disease of the optic nerve, but its effect on brain network topology is still unclear.This study aimed to investigate brain network alterations in NAION patients and to explore their relationship with functional impairment.Resting-state functional MRI data were collected from 23 NAION patients and 23 matched healthy control subjects.We used graph theory analysis to investigate the global and nodal network topological properties,and network-based statistical (NBS) methods were used to explore intergroup differences in functional connectivity (FC) strength.Compared to the control group, NAION patients had lower global efficiency, normalized clustering coefficient and small-world values and higher characteristic path length (P < 0.05). In the hub distributions of functional networks, the NAION group had one hub region disappearing and four hub regions appearing in nodal degree centrality (Dc), and two hubs disappearing and one hub region appearing in nodal betweenness centrality (Bc). The NAION group also had enhanced brain FC primarily associated with the frontal, prefrontal, parietal lobes and cerebellum. Furthermore, the right temporal pole, superior temporal gyrus (r = -0.424), the right inferior temporal gyrus (r = -0.414), the right cerebellar lobule Ⅵ (r = 0.450), and the left cerebellar lobule crus Ⅰ (r = 0.584) were significantly correlated with clinical severity.NAION patients show disruption and redistribution of FC in specific regions of the brain network, which may be associated with visual impairment.
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