Calotropis gigantea is one such plant.In this review the systematic position, vernacular names, distribution, phytochemistry and the economical values and their pharmacology morphology of the Calotropis gigantea are discussed.C. gigantea is extensively studied for its medicinal properties by advanced scientific techniques and a variety of bioactive compounds have been isolated from the different parts of the plant and were analysed pharmacologically.The plant is reported for analgesic activity, antimicrobial activity, antioxidant activity, antipyretic activity, insecticidal activity, cytotoxicity activity, hepatoprotective activity