A novel marker for prediabetic conditions: Uric acid-to-HDL cholesterol ratio

OBJECTIVES: The objective of this study was to identify a parameter that can facilitate the diagnosis of prediabetes and predict the likelihood of its development in individuals at high risk.METHODS: In this retrospective study, the study population was selected from Bolu Abant Izzet Baysal University Hospital's patients.Participants were divided into two groups, prediabetes and healthy group.We excluded individuals with certain conditions or taking certain medications.The study compared the ratios of uric acid to high-density lipoprotein (HDL) between the two groups and identified the optimal point of differentiation.RESULTS: The study analyzed data from 228 individuals, including 125 with prediabetes and 103 healthy controls.Those with prediabetes had a significantly higher median UHR (0.13 (0.07-0.24) %) compared to healthy individuals (0.09 (0.05-0.16) %) (p < 0.001).Higher UHR values were associated with a greater risk of prediabetes.A UHR cut-off points greater than 0.11 % had a sensitivity of 74 % and specificity of 69 % in detecting prediabetes.CONCLUSION: The study provides evidence that UHR can serve as a practical and valuable diagnostic and screening tool for prediabetes (Tab.2, Fig. 1, Ref. 23).