肺
肺癌
医学
芯片上器官
哮喘
动物模型
体内
微流控芯片
肺纤维化
病理
呼吸系统
病态的
生物信息学
免疫学
生物
内科学
微流控
纳米技术
生物技术
材料科学
作者
Dinesh O. Shah,Bhavarth P. Dave,Mehul R. Chorawala,Bhupendra G. Prajapati,Sudarshan Singh,Gehan M. Elossaily,Mohd Nazam Ansari,Nemat Ali
出处
期刊:ACS omega
[American Chemical Society]
日期:2024-03-07
标识
DOI:10.1021/acsomega.3c10271
摘要
Pulmonary diseases like asthma, chronic obstructive pulmonary disorder, lung fibrosis, and lung cancer pose a significant burden to global human health. Many of these complications arise as a result of exposure to particulate matter (PM), which has been examined in several preclinical and clinical trials for its effect on several respiratory diseases. Particulate matter of size less than 2.5 μm (PM2.5) has been known to inflict unforeseen repercussions, although data from epidemiological studies to back this are pending. Conventionally utilized two-dimensional (2D) cell culture and preclinical animal models have provided insufficient benefits in emulating the in vivo physiological and pathological pulmonary conditions. Three-dimensional (3D) structural models, including organ-on-a-chip models, have experienced a developmental upsurge in recent times. Lung-on-a-chip models have the potential to simulate the specific features of the lungs. With the advancement of technology, an emerging and advanced technique termed microfluidic organ-on-a-chip has been developed with the aim of identifying the complexity of the respiratory cellular microenvironment of the body. In the present Review, the role of lung-on-a-chip modeling in reproducing pulmonary complications has been explored, with a specific emphasis on PM2.5-induced pulmonary complications.
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