信号转导
细胞生物学
干扰素基因刺激剂
生物
刺
免疫系统
胞浆
功能(生物学)
磷酸化
先天免疫系统
免疫学
生物化学
酶
航空航天工程
工程类
作者
Caixia Liu,Jingyi Yang,Jiaxin Zheng,Jianmian Fu,Weisi Wang,Liping Duan,Xuhong Qian,Yangyang Yang
出处
期刊:ChemBioChem
[Wiley]
日期:2023-04-26
卷期号:24 (10)
被引量:2
标识
DOI:10.1002/cbic.202300147
摘要
Phase separation is a crucial biophysical process that governs cellular signaling and function. This process allows biomolecules to separate and form membraneless compartments in response to both extra- and intra-cellular stimuli. Recently, the identification of phase separation in different immune signaling pathways, including the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway, has shed light on its tight association with pathological processes such as viral infections, cancers, and inflammatory diseases. In this review, we present the phase separation in cGAS-STING signaling, along with its related cellular regulatory functions. Furthermore, we discuss the introduction of therapeutics targeting cGAS-STING signaling, which plays a pivotal role in cancer progression.
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