内分泌学
内科学
脂肪变性
白色脂肪组织
脂肪生成
脂肪肝
脂肪酸合酶
褐色脂肪组织
脂肪组织
产热
化学
甘油三酯
脂肪性肝炎
脂质代谢
生物
医学
胆固醇
疾病
作者
Sadra Samavarchi Tehrani,Golnaz Goodarzi,Ghodratollah Panahi,Fahimeh Zamani-Garmsiri,Reza Meshkani
出处
期刊:Life Sciences
[Elsevier]
日期:2023-06-01
卷期号:323: 121706-121706
被引量:3
标识
DOI:10.1016/j.lfs.2023.121706
摘要
The valuable effects of metformin (MET) and morin (MOR) in the improvement of NAFLD have been proposed, nevertheless, their combination impacts were not investigated so far. We determined the therapeutic effects of combined MET and MOR treatment in high-fat diet (HFD)-induced Non-alcoholic fatty liver disease (NAFLD) mice.C57BL/6 mice were fed on an HFD for 15 weeks. Animals were allotted into various groups and supplemented with MET (230 mg/kg), MOR (100 mg/kg), and MET + MOR (230 mg/kg + 100 mg/kg).MET in combination with MOR reduced body and liver weight in HFD-fed mice. A significant decrease in fasting blood glucose and improvement in glucose tolerance was observed in HFD mice treated with MET + MOR. Supplementation with MET + MOR led to a decline in hepatic triglyceride levels and this impact was associated with diminished expression of fatty-acid synthase (FAS) and elevated expression of carnitine palmitoyl transferase 1 (CPT1) and phospho-Acetyl-CoA Carboxylase (p-ACC). Moreover, MET combined with MOR alleviates hepatic inflammation through the polarization of macrophages to the M2 phenotype, decreasing the infiltration of macrophages and lowering the protein level of NF-kB. MET and MOR in combination reduce the size and weight of epididymal white adipose tissue (eWAT), and subcutaneous WAT (sWAT), whereas improves cold tolerance, BAT activity, and mitochondrial biogenesis. Combination therapy results in stimulating brown-like adipocyte (beige) formation in the sWAT of HFD mice.These results suggest that the combination of MET and MOR has a protective effect on hepatic steatosis, which may use as a candidate therapeutic for the improvement of NAFLD.
科研通智能强力驱动
Strongly Powered by AbleSci AI