Synthesis, Characterization, and Molecular Docking Studies of 3-Hydroxy-2-(1-methyl-3- (trifluoromethyl)-1H-pyrazole-4-carbonyl)cyclohex-2-en-1-ones

Three new 3-hydroxy-2-(1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carbonyl)cyclohex-2-en-1-ones (4a-c) were synthesized using aromatic formic acid as starting material. The structures of the compounds were confirmed by spectral (infrared, proton nuclear magnetic resonance, carbon-13 nuclear magnetic resonance, and HRMS) data. The molecular docking studies of the compounds were carried out to predict the possible 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitory activity. All the compounds exhibited activity in HPPD inhibitory.. KEYWORDS :4-Hydroxyphenylpyruvate dioxygenase inhibitory, Molecular docking, Pyrazolylcyclohexanones.