立体中心
化学
同族
戒指(化学)
立体化学
Knoevenagel冷凝
全合成
环氧化物
对映选择合成
有机化学
催化作用
作者
Zhihui Xie,Shengfu Duan,Haodong Wang,Tingyan Li,Zhixiang Xie
标识
DOI:10.1021/acs.orglett.4c00380
摘要
The asymmetric total syntheses of ent-stachybotrin C and its congener have been accomplished through a convergent approach in the longest linear sequence of 12 steps from commercially available materials, respectively. Noteworthy transformation of the synthesis involved a cascade Knoevenagel condensation/Hantzsch ester reduction/epoxide ring-opening/transetherification to construct the core pyran ring with two adjacent stereocenters.
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