微泡
血小板
凝结
生物标志物
免疫学
疾病
血小板活化
医学
细胞外小泡
生物
细胞生物学
病理
小RNA
内科学
遗传学
基因
作者
Imène Melki,Nicolas Tessandier,Anne Zufferey,Éric Boilard
出处
期刊:Platelets
[Informa]
日期:2017-01-19
卷期号:28 (3): 214-221
被引量:168
标识
DOI:10.1080/09537104.2016.1265924
摘要
Interest in cell-derived extracellular vesicles and their physiological and pathological implications is constantly growing. Microvesicles, also known as microparticles, are small extracellular vesicles released by cells in response to activation or apoptosis. Among the different microvesicles present in the blood of healthy individuals, platelet-derived microvesicles (PMVs) are the most abundant. Their characterization has revealed a heterogeneous cargo that includes a set of adhesion molecules. Similarly to platelets, PMVs are also involved in thrombosis through support of the coagulation cascade. The levels of circulatory PMVs are altered during several disease manifestations such as coagulation disorders, rheumatoid arthritis, systemic lupus erythematosus, cancers, cardiovascular diseases, and infections, pointing to their potential contribution to disease and their development as a biomarker. This review highlights recent findings in the field of PMV research and addresses their contribution to both healthy and diseased states.
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