微生物学
脓肿分枝杆菌
生物膜
抗菌剂
克拉霉素
阿米卡星
偶发分枝杆菌
环丙沙星
亚胺培南
生物
磺胺甲恶唑
抗药性
抗生素
抗生素耐药性
分枝杆菌
细菌
遗传学
作者
Vanessa da Costa Flores,Fallon dos Santos Siqueira,Caren Rigon Mizdal,Pauline Cordenonsi Bonez,Vanessa Albertina Agertt,Sílvio Terra Stefanello,Grazielle Guidolin Rossi,Marli Matiko Anraku de Campos
标识
DOI:10.1016/j.micpath.2016.08.017
摘要
Rapidly growing mycobacteria (RGM) are opportunistic pathogens found in the environment. When in biofilms, mycobacteria is highly resistant to antibacterial treatments. The purpose of this study is to evaluate the antibiofilm activity of antimicrobials commonly used in therapy against mycobacteria. The antimicrobial susceptibility of Mycobacterium abscessus, Mycobacterium fortuitum and Mycobacterium massiliense was determined in planktonic and sessile populations. The antimicrobials amikacin, ciprofloxacin, clarithromycin, doxycycline, imipenem and sulfamethoxazole were tested. For each drug, it was evaluated the susceptibility of the pathogen, the ability to inhibit biofilm formation and the resistance of biofilms to antimicrobial activity. Results showed although, the antimicrobials tested are used as an alternative therapy for RGM, M. abscessus proved to be resistant to clarithromycin, beside that, M. massiliense showed a resistant profile to clarithromycin and sulfamethoxazole. Moreover, the inhibition of biofilm formation and its destruction have not been fully met. Considering that the biofilms are a known form of bacterial resistance, the failure of alternatives to inhibit or destroy biofilms can trigger the recurrence of infections. In RGM, besides causing treatment failures, biofilms are a factor of pathogenic risk, since these microorganisms are found in environmental sources and can cause infections easily.
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