谷氨酰胺
单纯疱疹病毒
病毒
病毒学
病毒潜伏期
免疫系统
生物
HSL和HSV色彩空间
CD8型
疱疹病毒科
免疫学
下调和上调
病毒性疾病
病毒复制
基因
氨基酸
生物化学
作者
Kening Wang,Yo Hoshino,Kennichi Dowdell,Marta Bosch–Marcé,Timothy G. Myers,Marjorie Sarmiento,Lesley Pesnicak,Philip R. Krause,Jeffrey I. Cohen
摘要
Chronic viral infections are difficult to treat, and new approaches are needed, particularly those aimed at reducing reactivation by enhancing immune responses. Herpes simplex virus (HSV) establishes latency and reactivates frequently, and breakthrough reactivation can occur despite suppressive antiviral therapy. Virus-specific T cells are important to control HSV, and proliferation of activated T cells requires increased metabolism of glutamine. Here, we found that supplementation with oral glutamine reduced virus reactivation in latently HSV-1-infected mice and HSV-2-infected guinea pigs. Transcriptome analysis of trigeminal ganglia from latently HSV-1-infected, glutamine-treated WT mice showed upregulation of several IFN-γ-inducible genes. In contrast to WT mice, supplemental glutamine was ineffective in reducing the rate of HSV-1 reactivation in latently HSV-1-infected IFN-γ-KO mice. Mice treated with glutamine also had higher numbers of HSV-specific IFN-γ-producing CD8 T cells in latently infected ganglia. Thus, glutamine may enhance the IFN-γ-associated immune response and reduce the rate of reactivation of latent virus infection.
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