医学
氧化磷酸化
细胞生物学
肌萎缩侧索硬化
2型糖尿病
作者
Nicole B. Flemming,Linda A. Gallo,Micheal S. Ward,Josephine M. Forbes
出处
期刊:Current Drug Targets
[Bentham Science]
日期:2016-08-31
卷期号:17 (12): 1341-1349
被引量:15
标识
DOI:10.2174/1389450116666150727114410
摘要
Mitochondria produce the majority of cellular energy via the slow burn of substrates such as glucose, free fatty acids and ketones. In diabetes, altered mitochondrial energetics and substrate utilisation may explain, in part, an organ's susceptibility to complications. This is particularly evident at sites such as the kidney, heart, neurons and retina, which have high energy demands and oxygen consumption rates to meet functional requirements. Within this review we highlight the recent research implicating mitochondrial dysfunction, with particular focus on the contribution of mitochondrial reactive oxygen species, on the development and progression of diabetes complications. Finally, we discuss the current strategies which are being assessed to combat mitochondrial dysfunction in diabetes complications.
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