Engineered BioAIE photosensitizer from natural cryptolepine: Amplifying type I/II ROS for photodynamic eradication of bacteria

therapeutic efficacy was validated in a murine wound infection model. This work not only validates the substantial potential of TPA-CRY in photodynamic antibacterial therapy but also provides compelling evidence for the rational development of BioAIE-PSs via structural modification of ACQ-type natural products.