银纳米粒子
伤口愈合
自愈水凝胶
肿胀 的
金黄色葡萄球菌
核化学
水溶液
最小抑制浓度
化学
抗菌活性
材料科学
抗菌剂
纳米颗粒
高分子化学
医学
纳米技术
外科
细菌
生物
有机化学
复合材料
遗传学
作者
Anam Ahsan,Muhammad Asim Farooq
标识
DOI:10.1016/j.jddst.2019.101308
摘要
Silver nanoparticles were synthesized from cabbage (Brassica oleracia capitate) extract following green chemistry approach and characterized by UV–Vis spectroscopy, DLS, SEM and FT-IR. Furthermore, PVA hydrogel patches loaded with these green synthesized AgNPs and AgNP/clay/activated carbon biocomposites were designed and developed by Freeze-thaw method and their characterization was done by FT-IR and SEM. Swelling studies for these hydrogel patches were performed and overall thickness of these hydrogel patches lied between 0.34 and 0.36 mm. Antibacterial activity of hydrogel patches (10% aqueous soln.) was checked against two representative bacterial strains (Staphylococcus aureus and Escherichia coli) using microdilution method. The minimum inhibitory concentration (MIC) of AgNP-HP and AgNP-Bc-HP for Staphylococcus aureus was 25 μg/mL and 12.5 μg/mL respectively whereas for Escherichia coli it was 3.13 μg/mL and 6.3 μg/mL respectively. Wound healing study was carried out using rabbits as experimental models after giving wound incision on the dorsal skin of these rabbits. Wounds were grossly observed for wound healing over a period of 20 days after application of hydrogel patches on regular basis. Wound healing score was recorded after every 5 days and skin biopsies were taken at 2nd and 3rd weeks of study for histopathological examination. These PVA hydrogel patches proved to be an excellent candidate for wound healing.
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