粪便
链霉菌
巴非霉素
链霉菌科
立体化学
生物
微生物学
抗寄生虫的
衍生工具(金融)
病毒学
化学
放线菌
生物化学
细菌
医学
遗传学
经济
细胞凋亡
自噬
病理
金融经济学
作者
Xi Xie,Shengsheng Lu,Xiaoyan Pan,Min Zou,Fangfang Li,Haixing Lin,Jianan Hu,Sheng Di Fan,Jian He
标识
DOI:10.1021/acs.jnatprod.0c01243
摘要
A new bafilomycin derivative (1) and another seven known bafilomycins (2–8) were isolated from feces-derived Streptomyces sp. HTL16. The structure of 1 was elucidated by 1D and 2D NMR spectroscopic analysis. Biological testing demonstrated that these bafilomycins exhibited potent antiviral activities against the influenza A and SARS-CoV-2 viruses, with IC50 values in the nanomolar range, by inhibiting the activity of endosomal ATP-driven proton pumps.
科研通智能强力驱动
Strongly Powered by AbleSci AI