中性粒细胞胞外陷阱
血小板
免疫学
止血
全球生产总值
败血症
血栓形成
炎症
受体
趋化因子
医学
血小板活化
免疫系统
先天免疫系统
内科学
作者
Kimberly Martinod,Carsten Deppermann
出处
期刊:Platelets
[Informa]
日期:2020-09-08
卷期号:32 (3): 314-324
被引量:88
标识
DOI:10.1080/09537104.2020.1817360
摘要
Platelets are increasingly being recognized for playing roles beyond thrombosis and hemostasis. Today we know that they mediate inflammation by direct interactions with innate immune cells or secretion of cytokines/chemokines. Here we review their interactions with neutrophils and monocytes/macrophages in infection and sepsis, stroke, myocardial infarction and venous thromboembolism. We discuss new roles for platelet surface receptors like GPVI or GPIb and also look at platelet contributions to the formation of neutrophil extracellular traps (NETs) as well as to deep vein thrombosis during infection, e.g. in COVID-19 patients.
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