Comparison of Fractional Picosecond 1064-nm Laser and Fractional Carbon Dioxide Laser for Treating Atrophic Acne Scars: A Randomized Split-Face Trial

痤疮疤痕 二氧化碳激光器 医学 疤痕 色素沉着 皮肤病科 痤疮 激光器 不利影响 萎缩 外科 病理 内科学 激光手术 光学 物理
作者
Punyaphat Sirithanabadeekul,Ploypailin Tantrapornpong,Bheeratida Rattakul,Nalinee Sutthipisal,Wilai Thanasarnaksorn
出处
期刊:Dermatologic Surgery [Ovid Technologies (Wolters Kluwer)]
卷期号:47 (2): e58-e65 被引量:22
标识
DOI:10.1097/dss.0000000000002572
摘要

BACKGROUND To date, no studies have compared the fractional picosecond 1064-nm laser (FxPico) and fractional carbon dioxide laser (FxCO 2 ) for the treatment of acne scars. OBJECTIVE To compare the efficacy and safety between FxPico and FxCO 2 for treating facial atrophic acne scars. MATERIALS AND METHODS Twenty-five Asian patients with mild to moderate atrophic acne scars underwent single sessions of randomized split-face treatment with FxPico and FxCO 2 . Clinical efficacy was assessed by photographs, skin imaging analysis, and patient satisfaction. The adverse events were recorded on every visit. Skin biopsies were performed immediately and 3 months after treatment. RESULTS The physician improvement scores for skin texture and atrophy significantly increased on the FxPico sides, but no significant difference was observed between FxPico and FxCO 2 . Skin imaging also showed significant improvement on both sides for scar volume. Postinflammatory hyperpigmentation (PIH) was not reported on FxPico sides, whereas 6 patients (24%) experienced mild PIH on FxCO 2 sides. Immediate post-FxPico skin biopsy revealed laser-induced optical breakdown with photoacoustic columns. Collagen and elastic fibers increased at 3 months after both treatments. CONCLUSION FxPico was as effective as FxCO 2 in treating atrophic acne scars, correlating with evidence of tissue remodeling with more safety profiles.
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