A Fluorescent Turn‐on Probe Based on Zn‐doped AgIn5S8 Quantum Dots for Imaging of Hydrogen Sulfide in Living Cells

Abstract H 2 S has been identified as endogenously generated gasotransmitter in mammalian which acts essential role in various physiological and pathological processes. In this work, we reported the use of hydrophilic, low‐toxic and photostable Zn‐doped AgIn 5 S 8 quantum dots (ZAIS QDs) in H 2 S detection. Copper ions, acting as recognition moieties, are conjugated on the surface of ZAIS QD to construct the fluorescent probe. The weak fluorescence signal of the probe owing to the quenching effect of paramagnetic Cu 2+ center on ZAIS QDs can exhibit significant fluorescence turn‐on property upon the addition of H 2 S. Simultaneously, the probe possesses high sensitivity at physiological pH, excellent membrane permeability and dose‐dependent fluorescence imaging of exogenous H 2 S in living cells.