重性抑郁障碍
双相情感障碍
心理学
功能磁共振成像
楔前
额上回
内科学
静息状态功能磁共振成像
心脏病学
顶叶上小叶
听力学
顶叶下小叶
精神科
神经科学
医学
认知
作者
Xiaowei Jiang,Shinan Fu,Yin Zhang,Jiahui Kang,Xinrui Wang,Yifang Zhou,Shengnan Wei,Feng Wu,Liang Kong,Fei Wang,Yanqing Tang
标识
DOI:10.1016/j.jad.2019.09.063
摘要
It is difficult to distinguish bipolar disorder (BD) from major depressive disorder (MDD), especially with the initial depressive episode. In this study, we compared neural activities of BD and MDD patients during the first-episode (FE) to investigate common and distinct neural activities and further explore predictive indicators in the two diseases. FE-MDD patients were performed resting state functional magnetic resonance imaging and followed up after scanning. After follow-up, FE-MDD patients were regrouped into FE-BD and FE-MDD patients. The study included 24 FE-BD patients, 28 FE-MDD patients, and 30 age- and sex-matched healthy controls (HC) to investigate neural activities with regional homogeneity (ReHo) analysis among the 3 groups. Compared to HC, FE-BD patients displayed significantly higher ReHo values in the superior frontal gyrus, the medial superior frontal gyrus within right-side cerebral hemisphere than FE-MDD patients and HC. Compared to HC, FE-BD and FE-MDD patients displayed significant decreased ReHo values in the paracentral lobule, the precuneus and the median cingulate and paracingulate gyrus within bilateral cerebral hemisphere, and the postcentral gyrus and the precentral gyrus within the right-side. FE-BD displayed significant lower ReHo values than FE-MDD patients in these regions. The potential effects of medicine, age, course of disease and handedness on results could not be ignored. Abnormal neural activities of frontoparietal network may provide common and distinct markers to affective disorders and scientific basis for further prediction researches of affective disorders.
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