线粒体
活性氧
醛固酮
化学
细胞生物学
肾素-血管紧张素系统
脂解
功能(生物学)
分泌物
生物化学
内科学
内分泌学
生物
血压
医学
脂肪组织
作者
Mark Domondon,Anna B. Nikiforova,Kristine Y. DeLeon‐Pennell,Daria V. Ilatovskaya
出处
期刊:American Journal of Physiology-renal Physiology
[American Physiological Society]
日期:2019-11-01
卷期号:317 (5): F1164-F1168
被引量:11
标识
DOI:10.1152/ajprenal.00384.2019
摘要
Natriuretic peptides (NPs) are well known to promote renal Na + excretion, counteracting the effects of the renin-angiotensin-aldosterone system. Thus, NPs serve as a key component in the maintenance of blood pressure, influencing fluid retention capabilities via osmoregulation. Recently, NPs have been shown to affect lipolysis and enhance lipid oxidation and mitochondrial respiration. Here, we provide an overview of current knowledge about the relationship between NPs and mitochondria-mediated processes such as reactive oxygen species production, Ca 2+ signaling, and apoptosis. Establishing a clear physiological and mechanistic connection between NPs and mitochondria in the cardiovascular system will open new avenues of research aimed at understanding and potentially using it as a therapeutic target from a completely new angle.
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