缺氧(环境)
细胞生物学
肿瘤缺氧
肿瘤微环境
HIF1A型
间歇性缺氧
缺氧诱导因子1
先天免疫系统
血管生成
转录因子
免疫学
出处
期刊:Physiology
[American Physiological Society]
日期:2021-03-01
卷期号:36 (2): 73-83
被引量:4
标识
DOI:10.1152/physiol.00034.2020
摘要
Activation of the innate and adaptive immune systems represents a promising strategy for defeating cancer. However, during tumor progression, cancer cells battle to shift the balance from immune activation to immunosuppression. Critical sites of this battle are regions of intratumoral hypoxia, and a major driving force for immunosuppression is the activity of hypoxia-inducible factors, which regulate the transcription of large batteries of genes in both cancer and stromal cells that block the infiltration and activity of cytotoxic T lymphocytes and natural killer cells, while stimulating the infiltration and activity of regulatory T cells, myeloid-derived suppressor cells, and tumor-associated macrophages. Targeting hypoxia-inducible factors or their target gene products may restore anticancer immunity and improve the response to immunotherapies.
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