硫黄
亲核细胞
烷基
化学
三角双锥分子几何
路易斯酸
催化作用
偶联反应
组合化学
金属
有机化学
分子
作者
Min Zhou,Jet Tsien,Tian Qin
标识
DOI:10.1002/anie.201915425
摘要
Abstract Despite the tremendous utilities of metal‐mediated cross‐couplings in modern organic chemistry, coupling reactions involving nitrogenous heteroarenes remain a challenging undertaking – coordination of Lewis basic atoms into metal centers often necessitate elevated temperature, high catalyst loading, etc. Herein, we report a sulfur (IV) mediated cross‐coupling amendable for the efficient synthesis of heteroaromatic substrates. Addition of heteroaryl nucleophiles to a simple, readily‐accessible alkyl sulfinyl (IV) chloride allows formation of a trigonal bipyramidal sulfurane intermediate. Reductive elimination therefrom provides bis‐heteroaryl products in a practical and efficient fashion.
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