白藜芦醇
医学
科克伦图书馆
病理生理学
疾病
科学网
生物信息学
斯科普斯
病态的
神经炎症
神经科学
老年斑
阿尔茨海默病
药理学
神经保护
神经退行性变
梅德林
氧化应激
评论文章
发病机制
荟萃分析
内科学
心理学
生物
生物化学
作者
Júlia Canto e Sousa,Ana Carolina Fauaze Santana,Gabriela Jesus Prado Magalhães
标识
DOI:10.1590/0004-282x20200010
摘要
ABSTRACT Background: Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive and irreversible loss of cognitive function. The presence of senile plaques is one of the pathological markers of the disease and is associated with the onset of neuroinflammatory mechanisms. The exact pathophysiology of AD has not been completely understood, and there are no curative therapies yet. Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a polyphenol that is noted for its antioxidant and anti-inflammatory properties. Objective: To review the role of resveratrol in the pathophysiological aspects of AD. Methods: This study carried out a literature review using PubMed/Medline, Virtual Health Library (VHL), Web of Sciences, SCOPUS and the Cochrane Library databases. Original research articles, describing both in vitro and in vivo experiments, published between 2008 and 2018, were included. Results: We identified 667 articles, of which 619 were excluded because they were repeated or did not follow the inclusion criteria. The present study includes the remaining 48 articles. Discussion: Resveratrol demonstrates beneficial and protective effects in AD models and seems to provide a promising therapeutic alternative. Conclusion: Although resveratrol appears to mitigate some pathophysiological aspects of AD, further studies are needed to prove the safety and efficacy of this compound in humans.
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