细胞外基质
胰岛素抵抗
整合素
脂肪组织
胰岛素
胰岛素受体
生物
细胞生物学
内分泌学
内科学
受体
医学
作者
Ashley S. Williams,Kang Li,David H. Wasserman
标识
DOI:10.1016/j.tem.2015.05.006
摘要
The extracellular matrix (ECM) is a highly-dynamic compartment that undergoes remodeling as a result of injury and repair. Over the past decade, mounting evidence in humans and rodents suggests that ECM remodeling is associated with diet-induced insulin resistance in several metabolic tissues. In addition, integrin receptors for the ECM have also been implicated in the regulation of insulin action. This review addresses what is currently known about the ECM, integrins, and insulin action in the muscle, liver, and adipose tissue. Understanding how ECM remodeling and integrin signaling regulate insulin action may aid in the development of new therapeutic targets for the treatment of insulin resistance and type 2 diabetes (T2D).
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