结合
多糖
聚合
聚合物
溶解度
化学
组合化学
戒指(化学)
高分子化学
材料科学
作者
Fangping Yang,Zhiwei Liu,Wenting Si,Ziyuan Song,Lichen Yin,Haoyu Tang
标识
DOI:10.1021/acsmacrolett.2c00205
摘要
Polysaccharide-polypeptide conjugates have gained a broad interest in mimicking the structure and bioactivity of peptidoglycans or proteoglycans for biomedical applications. Efficient and precise preparation of the conjugates is challenging and unresolved, mainly because of the mismatched solubility between polysaccharide initiators and N-carboxyanhydrides (NCAs), which frequently results in competing side reactions and oligomeric polypeptide chain. Herein, we report a facile and efficient strategy to prepare the conjugates with well-controlled polypeptide chain length (lp) directly from unmodified polysaccharides via a biphasic solution ring-opening polymerization. The effect of lp on surface antibacterial properties has been investigated. Elongating the lp can significantly potentiate the antibiofilm property of the conjugate coatings. Our results may provide opportunities to develop various polypeptide-based conjugates with well-defined structures toward versatile uses.
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