医学
类有机物
肺癌
体内
肺
癌症
纳米技术
癌症研究
神经科学
内科学
生物
材料科学
生物技术
作者
Heng-Hao Ma,Yuandong Zhu,Rui Zhou,Yaya Yu,Zhen-Zhen Xiao,Haibo Zhang
标识
DOI:10.1016/j.critrevonc.2022.103610
摘要
Lung cancer organoids (LCOs) have sprung up in more and more researching fields, because of their ability to recapitulate the three-dimensional structure and functions of the in vivo counterpart organs. However, the culture system for LCOs is still immature, resulting in limited success rate and low tumor purity when culturing LCOs. This is mainly due to the deficiency of an optimal formula of culture medium specially for LCOs. Various cytokines and small molecules have been added in the LCOs culturing system. Compound screening, considering both the mechanism of these molecules and the complexity of lung cancer types is warranted to optimize LCOs culture medium. As methods to culture LCOs increase in sophistication, this model will undoubtedly stand its ground in the coming years in every aspect of cancer researches, especially with major advantages in the field of personalized medicine and tumor microenvironment researches.
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