Sinomenine attenuates alcohol-induced acute liver injury via inhibiting oxidative stress, inflammation and apoptosis in mice

• SIN protects from alcohol-induced ALI. • SIN reduced oxidative stress by enhancing antioxidant enzyme levels and Nrf2/HO-1. • SIN decreased inflammation by inhibiting NLRP3 inflammasome and Akt/NF-κB pathway. • SIN inhibited apoptotic protein levels and down-regulated MAPK expressions.