微泡
骨髓
肿瘤微环境
癌症研究
黑色素瘤
细胞毒性
抗原呈递
免疫系统
抗原
免疫原性细胞死亡
免疫疗法
T细胞
免疫学
肿瘤细胞
生物
小RNA
体外
基因
生物化学
作者
Tingting Wang,Yan Qi,Dan Zhang,Qingle Song,Conglian Yang,Xiaomeng Hu,Yuling Bao,Yongdan Zhao,Zhiping Zhang
标识
DOI:10.1002/adfm.201703191
摘要
Abstract Various types of cell can change the cytoskeleton and shed microvesicles (MVs) with biomimic properties as parent cells in response to stimuli. To take use of the drug package capability of MVs and the potent antigen presentation property of dendritic cells (DCs), DC‐derived antigenic MVs are constructed by priming DCs with tumor‐derived MVs and then encapsulating a chemotherapeutic drug during MVs shedding. This kind of MVs exhibit significant inhibition on melanoma tumor growth and metastasis. The MV‐encapsulated chemotherapeutics can induce direct cytotoxicity and immunogenic cell death in tumor cells. Moreover, a robust antitumor immunity is induced in both, the tumor‐draining lymph node and the tumor microenvironment as the infiltration and activation of T lymphocytes increases. This kind of MVs is further explored in a hepatic ascites model with remarkable prolonged overall survival of mice. More importantly, the MVs can extend the survival of 60% mice more than 150 d without ascites even after rechallenging the tumor twice. This study demonstrates that antigenic MVs with chemotherapeutics possess great potential in cancer immunochemotherapy.
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