医学
内科学
淋巴瘤
单变量分析
胃肠病学
病态的
单中心
阶段(地层学)
侵袭性淋巴瘤
肺
多元分析
肿瘤科
美罗华
生物
古生物学
作者
Muchen Zhang,Min Zhou,Qi Song,Shuo Wang,Qingqing Shi,Li Wang,Fuhua Yan,Jieming Qu,Weili Zhao
出处
期刊:Lung Cancer
[Elsevier]
日期:2019-06-01
卷期号:132: 39-44
被引量:15
标识
DOI:10.1016/j.lungcan.2019.04.004
摘要
Background Pulmonary lymphoma arises primarily from the lung, which is extremely rare, or be secondarily involved by lymphoma. The clinical features, management, and prognostic factors have not been clearly identified. Methods Sixty-three patients with primary pulmonary lymphoma (PPL) and 117 patients with secondary pulmonary lymphoma (SPL) treated in our institution between June 2003 and December 2017 were retrospectively reviewed. Results MALT (67%) was the most common pathological subtype of PPL, while DLBCL (48%) was the most common subtype of SPL. Compared to the patients with PPL, the presence of B symptoms, advanced disease stage, intermediate-high or high risks of IPI and NCCN-IPI, elevated inflammatory parameters, and elevated cytokine levels were all observed in patients with SPL. Consolidation was the most frequent radiological finding in PPL cases, while nodules were the most frequent finding in SPL. With a median follow-up of 35 months (range 2–176), the estimated 3-year OS rates were 95%, 100%, 70% and 50% in indolent PPL, indolent SPL, aggressive PPL, and aggressive SPL, respectively. In indolent pulmonary lymphoma, none of the prognostic factors we studied significantly influenced survival of the patients. In aggressive pulmonary lymphoma, univariate analysis showed that NCCN-IPI was related to OS in PPL. Multivariate analysis showed that β2-MG was an independent prognostic factor for OS in SPL. Conclusions Primary and secondary pulmonary lymphoma differ in their clinical features and outcome. Furthermore, β2-MG is the independent prognostic factor for OS in patients with aggressive SPL.
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