Analysis of prognostic factors of advanced non-small cell lung cancer (NSCLC) patients after chemotherapy by Cox Proportional Hazard Model

Background and purpose:Non-small cell lung cancer (NSCLC) is the most frequent histological type of the lung cancer. There are significant differences of prognoses among the patients with advanced NSCLC patients after chemotherapy. The purpose of this study was to explore the prognostic factors of advanced NSCLC patients after chemotherapy. Methods:204 advanced NSCLC patients after chemotherapy were enrolled in the Oncology Center of Shandong Provincial Hospital from Feb.1998 to Jul.2006. Kaplan-Meier method and Log-rank time series analysis for the univariate analysis and Cox proportional hazard model for the multivariate analysis were used. Results:The median survival time was 12 .2 months, 1 year survival rate was 54.9%. The univariate analysis suggested that TNM staging (P=0.0075), KPS scoring (P=0.0151), chemotherapy regiman (P=0.0325), the chemotherapy cycles (P=0.0298) and the status of patients’ immediate response to the treatment (P=0.0061) significantly influenced survival of NSCLC. Multivariate analysis suggested that KPS scoring (P=0.019), TNM staging (P=0.011), and the status of patients’ immediate response to the treatment (P=0.009) were the independent factors of survival. Conclusion:KPS scoring, TNM staging and the status of patients’ immediate response to the treatment are the independent prognostic factors for advanced NSCLC patients after chemotherapy.