材料科学
光热治疗
磁共振成像
图像分辨率
穿透深度
纳米颗粒
渗透(战争)
纳米材料
核磁共振
钆
光学
生物医学工程
纳米技术
放射科
工程类
物理
冶金
医学
运筹学
作者
Longhua Ma,Yuxin Liu,Lidong Liu,Anqi Jiang,Fang Mao,Dongdong Liu,Lu Wang,Jing Zhou
标识
DOI:10.1002/adfm.201705057
摘要
Abstract Nanoparticle emitting short‐wave infrared (SWIR) light has received increased attention in the molecular imaging field due to its deeper tissue penetration, fast imaging, high sensitivity, and resolution. The simultaneously activated SWIR excited directly by an 808 nm laser and T 1 ‐weighted magnetic resonance imaging (MRI) signal are found in one single‐shell nanoparticle NaErF 4 @NaGdF 4 (Er@Gd), which is used as a dual‐modality imaging contrast agent in vivo to accurately determine the position of tumors. The conjugated cypate is then aggregated on the surface of Er@Gd@SiO 2 ‐Cy/bovine serum albumin. With the guidance of dual modality imaging, photothermal therapy is effectively used to ablate tumors in a mouse model. The design of single‐shell nanomaterial activation of SWIR imaging and MRI signals is expected to provide a new strategy for high penetration and spatial resolution cancer theranostics.
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