Ibuprofen tagged imine RT-COF-1 as customisable vehicle for controlled drug delivery application

Here, we have been synthesized imine linked covalent organic framework (RT-COF-1) using 1,3,5-tris(4-aminophenyl) benzene (TAPB) and 1,3,5-benzenetricarbaldehyde (BTCA) in 1:1 ratio with catalytic amount of glacial acetic acid at room temperature. Synthesized RT-COF1 has been confirmed using Powder X-ray diffraction (PXRD), Field Emission Scanning Electron Microscopy (FESEM), UV -Vis Spectroscopy, Photoluminescence Spectroscopy, Fourier transform infrared spectroscopy (FTIR), and BET Surface area analyzer. Then, synthesised RT-COF1 has been tagged to model drug i.e., ibuprofen (IBU) using simple coordination chemistry. The drug conjugated i.e., [email protected] was confirmed through UV and IR spectroscopy techniques. Importantly, the lone pair of electrons on nitrogen atom present in RT-COF1 forms hydrogen bonding with the model drug molecules. Prominently, the model drug profile i.e., loading and release rate has been analysed using spectroscopic analysis.