伐地那非
掺假者
吗啉
哌嗪
化学
药品
药理学
医学
传统医学
有机化学
西地那非
内科学
他达拉非
作者
Chunzheng Li,Xinzheng Wang,Sheng‐Ming Wu,Jianshi Zhao,Jiaojiao Fang,Hui Li,Yunlong Zhu,Kang Zhang,Jing Peng,Jie Mei,Weihua Li,Kai He,Na Wang,Fangting Dong
出处
期刊:Heliyon
[Elsevier]
日期:2023-04-01
卷期号:9 (4): e15418-e15418
被引量:3
标识
DOI:10.1016/j.heliyon.2023.e15418
摘要
A novel vardenafil analogue was identified in dietary supplement as an adulterant in herbal formulations. The structure of this analogue was elucidated using HRMS, NMR after extraction from the pulverized powder. It was named morphardenafil as a morpholine ring has replaced the N-ethyl piperazine ring in vardenafil. A tablet of this dietary supplement contained about 50 mg of unspecified morphardenafil, which is 2.5 – 20-times the prescriptive dosage of Levetra, the commercial formulation of the vardenafil monohydrochloride salt in the market and probably places unwary consumers at risk for potentially serious adverse effects or drug-drug interaction (DDI).
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