斑马鱼
生物累积
氧化应激
化学
水溶液
分子动力学
二硫化钼
污染物
纳米技术
环境化学
材料科学
生物化学
计算化学
有机化学
物理化学
基因
冶金
作者
Guohong Liu,Xiliang Yan,Chengjun Li,Song Hu,Jiachen Yan,Bing Yan
标识
DOI:10.1016/j.jhazmat.2022.130303
摘要
The environmental fate of transition-metal dichalcogenides (TMDCs) may be further complicated by interacting with existing pollutants, especially per- and polyfluoroalkyl substances (PFAS). However, due to their sheer volume, it is impossible to explore all possible interactions by simply utilizing experimental methods. Herein, we used two model TMDC nanosheets, molybdenum disulfide (MoS2) and tungsten disulfide (WS2), and seven PFAS to explore their interactions and subsequent impacts on model cell lines and zebrafish. Utilizing experimental methods and machine learning approaches, we showed that TMDCs-PFAS interactions can pose unique challenges due to their interaction-specific toxicity niches towards cell lines. Further in vivo experiments, together with molecular dynamics simulation, suggested that TMDCs-PFAS interactions in aqueous environments significantly increased their bioaccumulation in zebrafish towards different target organs, mostly due to the differences in loading PFAS. Such enhanced bioaccumulation increased the oxidative stress in zebrafish liver and intestine, as demonstrated by the increased reactive oxygen species (ROS) level and other enzyme activities, which eventually led to obvious histopathological alterations in the liver and intestine. Our study highlights the importance of exploring interactions between emerging and existing contaminants with state-of-art techniques in aqueous environments and its significance in safeguarding aquatic environment health.
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