压电
纳米纤维
聚己内酯
材料科学
生物医学工程
甘氨酸
传感器
超声波
纳米技术
复合材料
氨基酸
声学
医学
放射科
聚合物
化学
物理
生物化学
作者
Meysam T. Chorsi,Thinh T. Le,Feng Lin,Tra Vinikoor,Ritopa Das,James F. Stevens,Caitlyn Mundrane,Jinyoung Park,Khanh T. M. Tran,Yang Liu,Jacob Pfund,Rachel M. Thompson,He Wu,M. Jain,M. Daniela Morales-Acosta,Osama R. Bilal,Kazem Kazerounian,Horea Ilieş,Thanh D. Nguyen
出处
期刊:Science Advances
[American Association for the Advancement of Science]
日期:2023-06-14
卷期号:9 (24)
被引量:53
标识
DOI:10.1126/sciadv.adg6075
摘要
Amino acid crystals are an attractive piezoelectric material as they have an ultrahigh piezoelectric coefficient and have an appealing safety profile for medical implant applications. Unfortunately, solvent-cast films made from glycine crystals are brittle, quickly dissolve in body fluid, and lack crystal orientation control, reducing the overall piezoelectric effect. Here, we present a material processing strategy to create biodegradable, flexible, and piezoelectric nanofibers of glycine crystals embedded inside polycaprolactone (PCL). The glycine-PCL nanofiber film exhibits stable piezoelectric performance with a high ultrasound output of 334 kPa [under 0.15 voltage root-mean-square (Vrms)], which outperforms the state-of-the-art biodegradable transducers. We use this material to fabricate a biodegradable ultrasound transducer for facilitating the delivery of chemotherapeutic drug to the brain. The device remarkably enhances the animal survival time (twofold) in mice-bearing orthotopic glioblastoma models. The piezoelectric glycine-PCL presented here could offer an excellent platform not only for glioblastoma therapy but also for developing medical implantation fields.
科研通智能强力驱动
Strongly Powered by AbleSci AI