Ferredoxin 1 is essential for embryonic development and lipid homeostasis

生物 铁氧还蛋白 胚胎发生 生物化学 胚胎干细胞 铁稳态 平衡 计算生物学 细胞生物学 遗传学 基因 胚胎
作者
Shakur Mohibi,Yanhong Zhang,Vivian Perng,Mingyi Chen,Jin Zhang,Xinbin Chen
出处
期刊:eLife [eLife Sciences Publications Ltd]
卷期号:13 被引量:7
标识
DOI:10.7554/elife.91656
摘要

Mammalian ferredoxin 1 and 2 (FDX1/2) belong to an evolutionary conserved family of iron-sulfur cluster containing proteins and act as electron shutters between ferredoxin reductase (FDXR) and numerous proteins involved in critical biological pathways. FDX1 is involved in biogenesis of steroids and bile acids, Vitamin A/D metabolism, and lipoylation of tricarboxylic acid (TCA) cycle enzymes. FDX1 has been extensively characterized biochemically but its role in physiology and lipid metabolism has not been explored. In this study, we generated Fdx1-deficient mice and showed that knockout of both alleles of the Fdx1 gene led to embryonic lethality. We also showed that like Fdxr+/-+/-, Fdx1+/-+/- had a shorter life span and were prone to steatohepatitis. However, unlike Fdxr+/-+/-, Fdx1+/-+/- were not prone to spontaneous tumors. Additionally, we showed that FDX1 deficiency led to lipid droplet accumulation possibly via the ABCA1-SREBP1/2 pathway. Specifically, untargeted lipidomic analysis showed that FDX1 deficiency led to alterations in several classes of lipids, including cholesterol, triacylglycerides, acylcarnitines, ceramides, phospholipids and lysophospholipids. Taken together, our data indicate that FDX1 is essential for mammalian embryonic development and lipid homeostasis at both cellular and organismal levels.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
2秒前
2秒前
姜彦乔发布了新的文献求助10
3秒前
华仔应助萧一采纳,获得10
3秒前
余味应助zorro3574采纳,获得10
3秒前
Li完成签到,获得积分10
4秒前
li发布了新的文献求助30
5秒前
8888拉完成签到,获得积分10
5秒前
无何有之乡完成签到,获得积分10
5秒前
Focus_BG完成签到,获得积分10
8秒前
8秒前
王天一完成签到,获得积分10
8秒前
8秒前
9秒前
Lucky潇潇完成签到,获得积分10
9秒前
DrLuffy完成签到,获得积分10
10秒前
可乐SAMA发布了新的文献求助10
14秒前
猕猴桃完成签到,获得积分10
16秒前
后来应助愤怒的寻芹采纳,获得10
16秒前
x5kyi完成签到,获得积分10
18秒前
tym完成签到 ,获得积分10
19秒前
19秒前
66发完成签到,获得积分10
20秒前
萧一发布了新的文献求助10
22秒前
23秒前
青青河边草完成签到 ,获得积分10
24秒前
幽默的月光完成签到,获得积分10
25秒前
25秒前
11222浅发布了新的文献求助10
26秒前
腼腆的缘分完成签到,获得积分10
26秒前
27秒前
年轻晓露完成签到,获得积分20
27秒前
qiaoxi完成签到,获得积分10
28秒前
小橘子完成签到 ,获得积分10
28秒前
萧一完成签到,获得积分10
29秒前
悦耳破茧完成签到 ,获得积分10
29秒前
年轻晓露发布了新的文献求助10
30秒前
Whisper完成签到 ,获得积分10
31秒前
吕凯强完成签到 ,获得积分10
32秒前
开放映冬发布了新的文献求助10
32秒前
高分求助中
Introduction to Strong Mixing Conditions Volumes 1-3 500
Tip60 complex regulates eggshell formation and oviposition in the white-backed planthopper, providing effective targets for pest control 400
Optical and electric properties of monocrystalline synthetic diamond irradiated by neutrons 320
共融服務學習指南 300
Essentials of Pharmacoeconomics: Health Economics and Outcomes Research 3rd Edition. by Karen Rascati 300
Peking Blues // Liao San 300
Political Ideologies Their Origins and Impact 13 edition 240
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3801134
求助须知:如何正确求助?哪些是违规求助? 3346777
关于积分的说明 10330258
捐赠科研通 3063151
什么是DOI,文献DOI怎么找? 1681383
邀请新用户注册赠送积分活动 807540
科研通“疑难数据库(出版商)”最低求助积分说明 763728