前列腺癌
内科学
乳腺癌
内分泌学
前列腺
医学
肿瘤科
癌症
癌症研究
作者
Song Yi Bae,Kaylee Kamalanathan,Catalina Galeano-Garces,Badrinath R. Konety,Emmanuel S. Antonarakis,Jayant Parthasarathy,Jin Hong,Justin M. Drake
标识
DOI:10.1210/endocr/bqae022
摘要
Abstract Burgeoning evidence suggests that circulating tumor cells (CTCs) may disseminate into blood vessels at an early stage, seeding metastases in various cancers such as breast and prostate cancer. Simultaneously, the early-stage CTCs that settle in metastatic sites (termed disseminated tumor cells or DTCs) can enter dormancy, marking a potential source of late recurrence and therapy resistance. Thus, the presence of these early CTCs poses risks to patients but also holds potential benefits for early detection, treatment, and opportunities for possibly curative interventions. This review delves into the role of early DTCs in driving latent metastasis within breast and prostate cancer, emphasizing the importance of early CTC detection in these diseases. We further explore the correlation between early CTC detection and poor prognoses, contributing significantly to increased cancer mortality. Consequently, the detection of CTCs at an early stage emerges as a critical imperative for enhancing clinical diagnostics and allowing for early interventions.
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