生物
癌症研究
细胞生长
炎症
癌症
细胞
癌细胞
头颈部鳞状细胞癌
基底细胞
细胞生物学
免疫学
头颈部癌
医学
内科学
遗传学
作者
Zihui Li,Xiaoxin Zhang,Ké Li,Fuyan Li,Jun-long Kou,Yuhan Wang,Xu Wei,Sun Y,Jing Yue,Yuxian Song,QiuYa Yu,Haijia Yu,Shuai Wang,Shi Chen,Y Wang,Shuanshuan Xie,Xiangyang Zhu,Yifan Zhan,Guozhe Sun,Yanhong Ni
标识
DOI:10.1016/j.cellsig.2024.111096
摘要
IL-36 is known to mediate inflammation and fibrosis. Nevertheless, IL-36 signalling axis has also been implicated in cancer, although understanding of exact contribution of IL-36 to cancer progression is very limited, partly due to existence of multiple IL-36 ligands with agonistic and antagonistic function. Here we explored the role of IL-36 in oral squamous cell carcinoma (OSCC). Firstly, we analyzed expression of IL-36 ligands and receptor and found that the expression of IL-36γ was significantly higher in head and neck cancer (HNSCC) than that of normal tissues, and that the high expression of IL-36γ predicted poor clinical outcomes. Secondly, we investigated the direct effect of IL-36γ on OSCC cells and found that IL-36γ stimulated proliferation of OSCC cells with high expression of IL-36R expression. Interestingly, IL-36γ also promoted migration of OSCC cells with low to high IL-36R expression. Critically, both proliferation and migration of OSCC cells induced by IL-36γ were abrogated by anti-IL-36R mAb. Fittingly, RNA sequence analysis revealed that IL-36γ regulated genes involved in cell cycle and cell division. In summary, our results showed that IL-36γ can be a tumor-promoting factor, and targeting of IL-36R signalling may be a beneficial targeted therapy for patients with abnormal IL-36 signalling.
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