胰蛋白酶
生物传感器
纤维
材料科学
低语长廊波浪
生物医学工程
化学
纳米技术
光电子学
医学
生物化学
酶
谐振器
复合材料
作者
Zhenyu Ma,Jun Sun,Xiaolan Li,Wenjun Shan,Yongde Yan,Yongjun Liu
标识
DOI:10.1016/j.snb.2023.135125
摘要
Trypsin, a protease produced in the pancreas, plays a crucial role in various medical conditions, including acute pancreatitis, cystic fibrosis, and malnutrition, where abnormal trypsin levels are often implicated. Consequently, trypsin detection has emerged as a valuable diagnostic tool in clinical medicine. In this study, we introduced an integrated fiber sensor that capitalizes on the amplification and transduction capabilities of liquid crystals, coupled with the high sensitivity of the whispering gallery mode, to achieve precise trypsin detection. This innovative approach offers consecutive measurement and rapid response times, typically under 200 seconds, and remarkably low sample consumption, as little as 3 nL, potential for detection in capillary blood sampling. Furthermore, when subjected to validation tests for trypsin detection in human serum, our method demonstrated excellent consistency and reliability, with recovery ratios falling within the range of 97-112%. Beyond trypsin, this method's adaptability and versatility make it a universal technique with potential applications in the field of biosensing and biochemistry.
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