医学
心肌梗塞
经皮冠状动脉介入治疗
心脏病学
临床终点
内科学
动脉切除术
放射科
动脉
支架
临床试验
再狭窄
作者
Johan Bennett,Keir McCutcheon,Koen Ameloot,Maarten Vanhaverbeke,Pierluigi Lesizza,Gianluca Castaldi,Tom Adriaenssens,Lennert Minten,Pieter-Jan Palmers,Quentin de Hemptinne,W Wilde,Claudiu Ungureanu,Bert Vandeloo,Giuseppe Colletti,Patrick Coussement,Nicolás M. Van Mieghem,Jo Dens
标识
DOI:10.1016/j.carrev.2023.08.019
摘要
The percutaneous treatment of calcified coronary lesions remains challenging and is associated with worse clinical outcomes. In addition, coronary artery calcification is associated with more frequent peri-procedural myocardial infarction.The ShOckwave ballooN or Atherectomy with Rotablation in calcified coronary artery lesions (SONAR) study is an investigator-initiated, prospective, randomized, international, multicenter, open label trial (NCT05208749) comparing a lesion preparation strategy with either shockwave intravascular lithotripsy (IVL) or rotational atherectomy (RA) before drug-eluting stent implantation in 170 patients with moderate to severe calcified coronary lesions. The primary endpoint is difference in the rate of peri-procedural myocardial infarction. Key secondary endpoints include rate of peri-procedural microvascular dysfunction, peri-procedural myocardial injury, descriptive study of IMR measurements in calcified lesions, technical and procedural success, interaction between OCT calcium score and primary endpoint, 30-day and 1-year major adverse clinical events.The SONAR trial is the first randomized controlled trial comparing the incidence of peri-procedural myocardial infarction between 2 contemporary calcium modification strategies (Shockwave IVL and RA) in patients with calcified coronary artery lesions. Furthermore, for the first time, the incidence of peri-procedural microvascular dysfunction after Shockwave IVL and RA will be evaluated and compared.
科研通智能强力驱动
Strongly Powered by AbleSci AI