Advances of Wnt/β-catenin Signaling Pathway in Lung Cancer: A review.

Lung cancer is currently the leading cause of cancer mortality and morbidity worldwide and greatly burdens humanity. Therefore, the prevention and treatment of lung cancer remains a serious global problem. The Wnt/β-catenin signaling pathway also regulates tumor cell growth and invasion through epithelial-mesenchymal transition and tumor stem cells. In this review, we first summarise the role of the Wnt/β-catenin signaling pathway in lung cancer, focusing on the reported links in the Wnt/β-catenin signaling pathway that are relevant to lung cancer cell line growth, cell survival, and patient prognosis. Then describe the advances in the Wnt/β-catenin signaling pathway in lung cancer therapy, the precise regulation of the Wnt/β-catenin signaling pathway, that precise regulation of the Wnt/β-catenin signaling pathway should be used to balance anti-tumor effects and adverse events.