自愈水凝胶
多酚
化学
抗菌活性
没食子酸
大豆蛋白
贻贝
琼脂糖
生物化学
抗氧化剂
有机化学
生态学
生物
细菌
遗传学
作者
Rita Argenziano,Sara Viggiano,Rodolfo Esposito,Martina Schibeci,Rosa Gaglione,Rachele Castaldo,Luca Fusaro,Francesca Boccafoschi,Angela Arciello,Marina DellaGreca,Gennaro Gentile,Pierfrancesco Cerruti,Gerardino D’Errico,Lucia Panzella,Alessandra Napolitano
标识
DOI:10.1016/j.jcis.2023.08.170
摘要
Hypothesis. Implementation of tissue adhesives from natural sources endowed with good mechanical properties and underwater resistance still represents a challenging research goal. Inspired by the extraordinary wet adhesion properties of mussel byssus proteins resulting from interaction of catechol and amino residues, hydrogels from soy protein isolate (SPI) and selected polyphenols i.e. caffeic acid (CA), chlorogenic acid (CGA) and gallic acid (GA) under mild aerial oxidative conditions were prepared. Experiments: The hydrogels were subjected to chemical assays, ATR FT-IR and EPR spectroscopy, rheological and morphological SEM analysis. Mechanical tests were carried out on hydrogels prepared by inclusion of agarose. Biological tests included evaluation of the antibacterial and wound healing activity, and hemocompatibility. Findings. The decrease of free NH2 and SH groups of SPI, the EPR features, the good cohesive strength and excellent underwater resistance (15 days for SPI/GA) under conditions relevant to their use as surgical glues indicated an efficient interaction of the polyphenols with the protein in the hydrogels. The polyphenols greatly also improved the mechanical properties of the SPI/ agarose/polyphenols hydrogels. These latter proved biocompatible, hemocompatible, not harmful to skin, displayed durable adhesiveness and good water-vapour permeability. Excellent antibacterial properties and in some cases (SPI/CGA) a favourable wound healing activity on dermal fibroblasts was obtained.
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