Synergistic Effects of Walnut Oil and Nervonic Acid on Antioxidant Activity and Cognitive Impairment

-induced PC12 cells. Furthermore, WONA (1.63 g/kg) outperformed WO and NA in alleviating brain injury in CI mice. CI mice are those in which a cognitive impairment model is established by subcutaneously injecting D-galactose (900 mg/kg) daily for eight weeks, which induces neuronal damage, enhances oxidative stress, disrupts neurotransmitters balance, and elevates inflammatory factors. The results demonstrated that WONA CI and can be utilized as an innovative functional food ingredient or dietary supplement to effectively improve cognitive impairment.