放松(心理学)
材料科学
核磁共振
纳米颗粒
质子
钆
磁共振成像
共轭体系
结晶学
化学
纳米技术
聚合物
医学
心理学
社会心理学
物理
量子力学
冶金
放射科
复合材料
作者
Megan A Kaster,Mikail D. Levasseur,Thomas G. W. Edwardson,Michael Caldwell,Daniela Hofmann,Giulia Licciardi,Giacomo Parigi,Claudio Luchinat,Donald Hilvert,Thomas J. Meade
出处
期刊:ACS applied bio materials
[American Chemical Society]
日期:2023-01-10
卷期号:6 (2): 591-602
标识
DOI:10.1021/acsabm.2c00892
摘要
Diagnostic medical imaging utilizes magnetic resonance (MR) to provide anatomical, functional, and molecular information in a single scan. Nanoparticles are often labeled with Gd(III) complexes to amplify the MR signal of contrast agents (CAs) with large payloads and high proton relaxation efficiencies (relaxivity, r1). This study examined the MR performance of two structurally unique cages, AaLS-13 and OP, labeled with Gd(III). The cages have characteristics relevant for the development of theranostic platforms, including (i) well-defined structure, symmetry, and size; (ii) the amenability to extensive engineering; (iii) the adjustable loading of therapeutically relevant cargo molecules; (iv) high physical stability; and (v) facile manufacturing by microbial fermentation. The resulting conjugates showed significantly enhanced proton relaxivity (r1 = 11–18 mM–1 s–1 at 1.4 T) compared to the Gd(III) complex alone (r1 = 4 mM–1 s–1). Serum phantom images revealed 107% and 57% contrast enhancements for Gd(III)-labeled AaLS-13 and OP cages, respectively. Moreover, proton nuclear magnetic relaxation dispersion (1H NMRD) profiles showed maximum relaxivity values of 50 mM–1 s–1. Best-fit analyses of the 1H NMRD profiles attributed the high relaxivity of the Gd(III)-labeled cages to the slow molecular tumbling of the conjugates and restricted local motion of the conjugated Gd(III) complex.
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