Viscoelastic Mechanics: From Pathology and Cell Fate to Tissue Regeneration Biomaterial Development

Viscoelasticity is the mechanical feature of living tissues and the cellular extracellular matrix (ECM) and has been recognized as an essential biophysical cue in cell function and fate regulation, tissue development and homeostasis maintenance, and disease progression. These findings provide new insights for the development of biomaterials with comparable viscoelastic properties as native ECMs and the tissue matrix, displaying promising applications in regeneration medicine. In this review, the relationship between matrix viscoelasticity and tissue functions (e.g., development and regeneration) in physiological conditions and disease progression (e.g., aging, degenerative, fibrosis, and tumor) in pathological conditions will be especially highlighted to figure out the potential therapeutic target for disease treatment and inspiration for tissue regeneration related biomaterial development. Furthermore, findings and an understanding of the cell response to ECM viscoelasticity and the mechanism behind it are comprehensively summarized to provide a pathophysiological basis for viscoelastic biomaterials design. The advances of viscoelastic biomaterials on defect tissue repair are also reviewed, suggesting the significance of the native matrix matchable microenvironment on tissue regeneration. Although challenging, tunable viscoelastic biomaterials that match the mechanical properties of native tissues and ECMs show great promise. They could promote tissue regeneration, treat degenerative diseases, and support the development of organoids and artificial organs.