Antifungal isolates database of amphibian skin‐associated bacteria and function against emerging fungal pathogens

生物 两栖动物 壶菌病 寄主(生物学) 细菌 数据库 生态学 青蛙皮 微生物生态学 微生物学 动物 遗传学 化学 有机化学 计算机科学
作者
Douglas C. Woodhams,Ross A. Alford,Rachael E. Antwis,Holly Archer,Matthew H. Becker,Lisa K. Belden,Sara C. Bell,Molly C. Bletz,Joshua H. Daskin,Leyla R. Davis,Sandra V. Flechas,Antje Lauer,Antonio López González,Reid N. Harris,Whitney M. Holden,Myra C. Hughey,Roberto Ibáñez,Rob Knight,Jordan G. Kueneman,Falitiana Rabemananjara
出处
期刊:Ecology [Wiley]
卷期号:96 (2): 595-595 被引量:198
标识
DOI:10.1890/14-1837.1
摘要

Microbial symbionts of vertebrate skin have an important function in defense of the host against pathogens. In particular, the emerging chytrid fungus Batrachochytrium dendrobatidis , causes widespread disease in amphibians but can be inhibited via secondary metabolites produced by many different skin‐associated bacteria. Similarly, the fungal pathogens of terrestrial salamander eggs Mariannaea elegans and Rhizomucor variabilis are also inhibited by a variety of skin‐associated bacteria. Indeed, probiotic therapy against fungal diseases is a recent approach in conservation medicine with growing experimental support. We present a comprehensive Antifungal Isolates Database of amphibian skin‐associated bacteria that have been cultured, isolated, and tested for antifungal properties. At the start, this database includes nearly 2000 cultured bacterial isolates from 37 amphibian host species across 18 studies on five continents: Africa, Oceania, Europe, and North and South America. As the research community gathers information on additional isolates, the database will be updated periodically. The resulting database can serve as a conservation tool for amphibians and other organisms, and provides empirical data for comparative and bioinformatic studies. The database consists of a FASTA file containing 16S rRNA gene sequences of the bacterial isolates, and a metadata file containing information on the host species, life‐stage, geographic region, and antifungal capacity and taxonomic identity of the isolate.
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