医学
内科学
醋酸阿比特龙酯
前列腺癌
比例危险模型
催乳素
肿瘤科
危险系数
前列腺
前列腺特异性抗原
骨转移
激素
癌症
内分泌学
泌尿科
雄激素剥夺疗法
置信区间
作者
Tao Yang,Ying Li,Shuzhen Chen,Jiale Tian,Xuyou Zhu,Long Zhang,Wei Wang,Yingyi Qin,Jens Richter,Aseem Anand,Chengdang Xu,Yongnan Chi,Chenyang Wang,Cuidong Bian,Denglong Wu,Zhenfei Li,Shengsong Huang
出处
期刊:The Prostate
[Wiley]
日期:2022-06-23
卷期号:82 (13): 1284-1292
被引量:2
摘要
Abstract Background To investigate the prognostic value and potential therapeutic target of the baseline serum hormones in patients with metastatic castration‐resistant prostate cancer (mCRPC) treated with abiraterone. Methods This retrospective study was performed in patients with mCRPC receiving abiraterone acetate (AA) from July 2016 to September 2020. Patients who had serum hormone tests within 2 weeks before AA treatment were included. Univariate analysis and Cox regression were performed to evaluate the correlation of sex hormones with progression‐free survival (PFS) and overall survival (OS). Prolactin (PRL) expression in the clinical specimens was evaluated by immunohistochemistry. Bone metastases were quantified by automated Bone Scan Index (aBSI). Results The study included 61 patients with a median follow‐up of 19.0 months. Patients with lower baseline PRL levels (median) responded better to AA than those with higher baseline PRL levels as indicated by prostate‐specific antigen (PSA) reduction (PSA90, 66.7% vs. 25.8%, p = 0.001), PFS (19.6 vs. 7.9 months), and OS (52.8 vs. 19.2 months). Cox regression adjusted for clinical factors also confirmed that baseline PRL level was an independent predictive factor for PFS (hazard ratio = 1.096, p = 0.007). Prostatic PRL expression increased as the disease progressed. PRL expression was also detected in biopsy samples from bone metastasis but not in normal bone tissue, and the serum PRL levels were positively correlated with aBSIs ( r = 0.28, p = 0.037). Conclusions Serum PRL levels are predictive of response to AA in patients with mCRPC. Serum PRL levels are positively correlated with the volume of metastatic bone disease.
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