钾通道
离子
材料科学
太赫兹辐射
离子通道
渗透
热传导
化学物理
钾通道
选择性
生物物理学
分子物理学
原子物理学
光电子学
膜
化学
物理
生物
复合材料
生物化学
催化作用
受体
有机化学
作者
Zhang-Hu Hu,Wenping Lv,De-Xuan Hui,Xiaojuan Wang,You‐Nian Wang
出处
期刊:Physical review
日期:2022-02-02
卷期号:105 (2)
被引量:9
标识
DOI:10.1103/physreve.105.024104
摘要
Potassium ion channels are essential elements in cellular electrical excitability and help maintain a resting potential in nonexcitable cells. Their universality is based on a unique combination of strong selectivity for K^{+} ions and near-diffusion-limited permeation efficiency. Understanding how the channel regulates the ion conduction would be instructive to the treatment of ion channelopathies. In this work, by means of molecular dynamics simulations, we demonstrate the significantly enhanced permeation of KcsA channel in reaction to an external terahertz wave, due to the effective response of the K^{+} ions in the selectivity filter regions of the channel. Compared to the case without external terahertz wave, a fourfold increase in the ion current through the channel is found.
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